IFN - β affects the angiogenic potential of circulating angiogenic 1 cells by activating calpain 1
نویسندگان
چکیده
1 cells by activating calpain 1 2 Cansu Yıldırım, Julie Favre, Ester M. Weijers, Ruud D. Fontijn, Michiel H. van Wijhe, 3 Sandra J. van Vliet, Reinier A. Boon, Pieter Koolwijk, Tineke C.T.M. van der Pouw Kraan 4 and Anton J.G. Horrevoets 5 Author Affiliations 6 1 Department of Molecular Cell Biology and Immunology, VU University Medical Center, 7 Amsterdam, The Netherlands. 8 2 Department of Physiology, Institute for Cardiovascular Research (ICaR-VU), VU University 9 Medical Center, Amsterdam, The Netherlands. 10 3 Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe 11 University, Frankfurt, Germany. 12 13 Running title: IFN-ß affects angiogenic cell number by calpain 1 activation. 14 15 16 Correspondence to Prof. Dr. Anton J. G. Horrevoets, Department of Molecular Cell Biology 17 and Immunology, VU University Medical Center, van der Boechorststraat 7, 1081 BT 18 Amsterdam, The Netherlands. E-mail: [email protected] 19 20
منابع مشابه
IFN-β affects the angiogenic potential of circulating angiogenic cells by activating calpain 1.
Circulating angiogenic cells (CACs) are monocyte-derived cells with endothelial characteristics, which contribute to both angiogenesis and arteriogenesis in a paracrine way. Interferon-β (IFN-β) is known to inhibit these divergent processes in animals and patients. We hypothesized that IFN-β might act by affecting the differentiation and function of CACs. CACs were cultured from peripheral bloo...
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